Nicardipine

Nicardipine

Systematic (IUPAC) name
2-[benzyl(methyl)amino]ethylmethyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
Trade names	Cardene
AHFS/Drugs.com	monograph
MedlinePlus	a695032
Legal status	℞ (Prescription only)
Routes of administration	Oral, intravenous
Pharmacokinetic data
Protein binding	>95%
Biological half-life	8.6 hours
Identifiers
CAS Number	55985-32-5 Y
ATC code	C08CA04 (WHO)
PubChem	CID: 4474
IUPHAR/BPS	2559
DrugBank	DB00622 Y
ChemSpider	4319 Y
UNII	CZ5312222S Y
KEGG	D08270 Y
ChEMBL	CHEMBL1484 Y
Chemical data
Formula	C26H29N3O6
Molecular mass	479.525 g/mol
SMILES O=C(OCCN(Cc1ccccc1)C)\C2=C(\N/C(=C(/C(=O)OC)C2c3cccc([N+]([O-])=O)c3)C)C
InChI InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3 Y Key:ZBBHBTPTTSWHBA-UHFFFAOYSA-N Y
Physical data
Melting point	136–138 °C (277–280 °F)
(verify)

Nicardipine hydrochloride (Cardene) is a medication used to treat high blood pressure and angina. It belongs to the class of calcium channel blockers.

Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hypertension, and Raynaud's phenomenon. It is available in oral and intravenous formulations. Its mechanism of action and clinical effects closely resemble those of nifedipine and the other dihydropyridines (amlodipine, felodipine), except that nicardipine is more selective for cerebral and coronary blood vessels. Furthermore, nicardipine does not intrinsically decrease myocardial contractility and may be useful in the management of congestive heart failure. Nicardipine also has a longer half-life than nifedipine. Nicardipine was approved by the FDA in December 1988. The patent for both Cardene and Cardene SR expired in October 1995.

It has been used in percutaneous coronary intervention.