Outline of immunology

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The following outline is provided as an overview of and topical guide to immunology:

Immunology is the study of all aspects of the immune system in all organisms.[1] It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.

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Essence of immunology

Main article: Immunology

Branches of immunology

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History of immunology

Main article: History of immunology

General immunological concepts

  • Immunity against:

Components of the immune system

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  Adaptive immune system

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  • Kinds of Antibodies
  • Classification
  • Functions
  • Regions

  Innate immune system

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  • Positive
  • Negative

Organs of the immune system

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  Primary Lymphoid Organs

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  Secondary Lymphoid Organs

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Cells of the immune system

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  Myeloid Cells

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  Lymphoid Cells

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  Others

(Non-hematopoietic cells with immune functions)

  Hematopoiesis

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Molecules of the Immune System

Immune receptors

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   Antigen receptors

  • Stimulatory
  • Inhibitory
  • Accessory molecule (CD79)
  • Co-receptors
  • Accessory molecules

   Pattern recognition receptors (PRRs)

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  • Dectin 1 subfamily
  • DCIR subfamily
  • Class A - Trimers
  • Class B - Two transmembrane domains
  • Others
  • NLRA (A for acidic transactivating domain)
  • NLRX

   Complement receptors

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   Fc receptors

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  • Secreted Fc receptors

   Cytokine receptors

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  • Others
  • EPOR (Erythropoietin receptor) - Homodimer
  • G-CSFR (CD114) - Homodimer upon ligand binding
  • MPL (CD110, Thrombopoietin receptor) - Homodimer upon ligand binding
  • GHR (Growth hormone receptor) - Homodimer upon ligand binding
  • PRLR (Prolactin receptor)
  • Interleukin receptors
  • CX3CR1 (Fractalkine receptor)

   Natural killer cell receptors

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  • Activating KIRs
  • Two domains, long cytoplasmic tail
  • Two domains, short cytoplasmic tail
  • Three domains, long cytoplasmic tail
  • Three domains, short cytoplasmic tail

   Others

Antibodies

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Cytokines

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  • CX3CL1 (Fractalkine, Neurotactin)

MHCs

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Complement proteins

  • Early stage (divided by pathway)
  • Middle stage
  • Late stage
  • Complement pathway inhibitors

Antimicrobial peptides

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Transcription factors

  • T-bet - TH1 differentiation
  • GATA3 - TH2 differentiation
  • RORγT - TH17 differentiation
  • BCL6 - TFH differentiation
  • FoxP3 - Treg differentiation

Signaling pathways

Cell adhesion molecules (CAMs)

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  • Alpha subunits
  • Beta subunits
  • Dimers
  • Cytoadhesin receptor
  • Leukocyte-adhesion receptor:
  • Very late antigen receptor:
  • Others

Others

  • CD28 - Expressed by T Cells
  • CD278 (ICOS) - Homodimer, expressed by T Cells
  • CTLA-4 (CD152)
  • PD-1 (CD279)

Immune system disorders

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Hypersensitivity and Allergy

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  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • Foreign
  • Autoimmune
  • GVHD (Graft-versus-host disease)
  • Unknown/Multiple types
  • Foreign
  • Autoimmune

Immunodeficiency

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Cancers of the immune system

Myeloid diseases

Inflammatory diseases

Immunoproliferative immunoglobulin disorders

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Lymphatic organ disease

Immunologic techniques and tests

Immunology and Health

Immunologists

Main article: List of immunologists

Immunology lists

References

  1. Janeway's Immunobiology textbook Searchable free online version at the National Center for Biotechnology Information
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External links