<templatestyles src="Module:Hatnote/styles.css"></templatestyles>
PIPES
|
Names |
IUPAC name
1,4-Piperazinediethanesulfonic acid (IUPAC)
|
Other names
PIPES
|
Identifiers |
|
5625-37-6 Y |
ChemSpider |
72022 N |
Jmol 3D model |
Interactive image |
PubChem |
6992709 |
-
InChI=1S/C8H18N2O6S2/c11-17(12,13)7-5-9-1-2-10(4-3-9)6-8-18(14,15)16/h1-8H2,(H,11,12,13)(H,14,15,16) N
Key: IHPYMWDTONKSCO-UHFFFAOYSA-N N
-
InChI=1/C8H18N2O6S2/c11-17(12,13)7-5-9-1-2-10(4-3-9)6-8-18(14,15)16/h1-8H2,(H,11,12,13)(H,14,15,16)
Key: IHPYMWDTONKSCO-UHFFFAOYAG
|
-
C1CN(CCN1CCS(=O)(=O)O)CCS(=O)(=O)O
|
Properties |
|
C8H18N2O6S2 |
Molar mass |
302.37 |
Appearance |
White powder |
Melting point |
Decomposes above 300 °C |
Boiling point |
Decomposes |
|
1 g/L (100 °C) |
Vapor pressure |
{{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
N verify (what is YN ?) |
Infobox references |
|
|
PIPES is the common name for piperazine-N,N′-bis(2-ethanesulfonic acid), and frequently used buffering agent in biochemistry. It is an ethanesulfonic acid buffer developed by Good et al. in the 1960s.[1]
Applications
PIPES has pKa (6.76 at 25°C) near the physiological pH which makes it useful in cell culture work. Its effective buffering range is 6.1-7.5 at 25° C. PIPES has been documented minimizing lipid loss when buffering glutaraldehyde histology in plant and animal tissues.[2][3] Fungal zoospore fixation for fluorescence microscopy and electron microscopy were optimized with a combination of glutaraldehyde and formaldehyde in PIPES buffer.[4] It has a negligible capacity to bind divalent ions.
See also
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Salema, R. and Brando, I., J. Submicr. Cytol., 9, 79 (1973).
- ↑ Schiff, R.I. and Gennaro, J.F., Scaning Electron Microsc., 3, 449 (1979).
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
|
Simple piperazines
(no additional rings) |
|
Phenylpiperazines |
- Acaprazine
- Antrafenine
- Aripiprazole
- Batoprazine
- Bifeprunox
- BRL-15,572
- Ciprofloxacin
- CSP-2503
- Dapiprazole
- DCPP
- DMPP
- Diphenylpiperazine
- Dropropizine
- EGIS-12,233
- Elopiprazole
- Eltoprazine
- Enpiprazole
- Ensaculin
- Etoperidone
- Flesinoxan
- Flibanserin
- Fluprazine
- Itraconazole
- Ketoconazole
- Levodropropizine
- Lorpiprazole
- mCPP
- Mefway
- MeOPP
- Mepiprazole
- Naftopidil
- Naluzotan
- Naphthylpiperazine
- Nefazodone
- Niaprazine
- Oxypertine
- Pardoprunox
- pCPP
- pFPP
- Posaconazole
- S-14,506
- S-14,671
- S-15,535
- SB-258,585
- SB-271,046
- SB-357,134
- SB-399,885
- Sonepiprazole
- TFMPP
- Tolpiprazole
- Trazodone
- Urapidil
- Vesnarinone
- Vilazodone
- Vortioxetine
- WAY-100,135
- WAY-100,635
|
Benzylpiperazines |
|
Diphenylalkylpiperazines
(benzhydrylalkylpiperazines) |
|
Pyrimidinylpiperazines |
|
Pyridinylpiperazines |
|
Benzo(iso)thiazolylpiperazines |
|
Tricyclics
(piperazine attached via side chain) |
|
Others/Uncategorized |
|
<templatestyles src="Asbox/styles.css"></templatestyles>