PKLR

Pyruvate kinase, liver and RBC
PDB rendering based on 1liu.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2VGB, 2VGF, 2VGG, 2VGI, 4IMA, 4IP7
Identifiers
Symbols	PKLR ; PK1; PKL; PKR; PKRL; RPK
External IDs	OMIM: 609712 MGI: 97604 HomoloGene: 37286 ChEMBL: 1075126 GeneCards: PKLR Gene
EC number	2.7.1.40
Gene ontology Molecular function • magnesium ion binding • pyruvate kinase activity • ATP binding • potassium ion binding Cellular component • cytosol • extracellular exosome Biological process • response to hypoxia • carbohydrate metabolic process • glucose metabolic process • energy reserve metabolic process • ATP biosynthetic process • response to nutrient • response to heat • response to glucose • response to lithium ion • endocrine pancreas development • positive regulation of cellular metabolic process • cellular response to insulin stimulus • response to ATP • pyruvate biosynthetic process • small molecule metabolic process • response to cAMP • response to other organism • canonical glycolysis Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE PKLR 207858 s at tn.png
File:PBB GE PKLR 210451 at tn.png
File:PBB GE PKLR 222078 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5313	18770
Ensembl	ENSG00000143627	ENSMUSG00000041237
UniProt	P30613	E9Q509
RefSeq (mRNA)	NM_000298	NM_001099779
RefSeq (protein)	NP_000289	NP_001093249
Location (UCSC)	Chr 1: 155.29 – 155.3 Mb	Chr 3: 89.14 – 89.15 Mb
PubMed search	[1]	[2]

Pyruvate kinase isozymes R/L is an enzyme that in humans is encoded by the PKLR gene.

The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Alternatively spliced transcript variants encoding distinct isoforms have been described.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]

File:WP534.png

Glycolysis and Gluconeogenesis edit

See also

• Pyruvate kinase