PNU-282,987

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PNU-282,987
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Systematic (IUPAC) name
N-[(3'R)-1'-azabicyclo[2.2.2]oct-3'-yl]-4-chlorobenzamide
Identifiers
CAS Number 123464-89-1
PubChem CID: 11243536
ChEMBL CHEMBL177611 YesY
Chemical data
Formula C14H17ClN2O
Molecular mass 264.750
  • Clc3ccc(cc3)C(=O)NC1CN2CCC1CC2
  (verify)

PNU-282,987 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors.[1][2] In animal studies, it shows nootropic effects, and derivatives may be useful in the treatment of schizophrenia,[3][4] although PNU-282,987 is not suitable for use in humans because of excessive inhibition of the hERG antitarget.[5]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Redrobe, J. (2009). "Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice". European journal of pharmacology 602 (1): 58–65. doi:10.1016/j.ejphar.2008.09.035 PMID 18848931
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.



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