Phenazepam

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Phenazepam
Phenazepam.svg
Phenazepam ball-and-stick model.png
Systematic (IUPAC) name
7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Clinical data
Trade names see below
AHFS/Drugs.com International Drug Names
Legal status
  • DE: Anlage III (Prescription only)
  • UK: Class C
  • US: Not FDA approved
  • ℞ (Prescription only) (RU)
Dependence
liability		 High
Addiction
liability		 Moderate
Routes of
administration		 Oral, IM, IV
Pharmacokinetic data
Bioavailability 16,7% (rat)[1]
Metabolism Hepatic — aromatic oxidation and C3-hydroxylation[2]
Onset of action 1.5–4 hours
Biological half-life 6–18 hours (active metabolite up to 60 hours)
Excretion Renal
Identifiers
CAS Number 51753-57-2 YesY
ATC code none
PubChem CID: 40113
ChemSpider 36657 YesY
UNII 3DSB43090Z YesY
ChEMBL CHEMBLCHEMBL1709464 YesY
Chemical data
Formula C15H10BrClO
Molecular mass 347,966 g·mol-1
  • c1ccc(c(c1)C2=NCC(=O)Nc3c2cc(cc3)Br)Cl
  • InChI=1S/C15H10BrClN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20) YesY
  • Key:CGMJQQJSWIRRRL-UHFFFAOYSA-N N
 NYesY (what is this?)

Phenazepam is a benzodiazepine drug, which was developed in the Soviet Union in 1974 and now produced in Russia and some CIS countries. Phenazepam is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal syndrome and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety. Recently, phenazepam has gained popularity as a recreational drug; misuse has been reported in the United Kingdom,[3] Finland,[4] Sweden,[5] and the United States.[6]

Side effects

Side effects include hiccups, dizziness, loss of coordination and drowsiness, along with anterograde amnesia which can be quite pronounced at high doses.[7] As with other benzodiazepines, in case of abrupt discontinuation following prolonged use, severe withdrawal symptoms may occur including restlessness, anxiety, insomnia, seizures, convulsions and death, though because of its long half-life, these withdrawal symptoms may take two or more days to manifest.

Contraindications and special caution

Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, alcohol or drug-dependent individuals and individuals with comorbid psychiatric disorders.[8]

Phenazepam should not be taken with alcohol or any other CNS depressants. Phenazepam should not be used therapeutically for periods of longer than one month including tapering on and off the drug as recommended for any benzodiazepine in the British national formulary. Some patients may require longer term treatment.

Phenazepam was found to be a component in some herbal incense mixtures in Australia & New Zealand in 2011, namely "Kronic". The particular product variety was withdrawn shortly from the market after and replaced with a new formulation.[9]

Detection in biological fluids

Phenazepam may be measured in blood or plasma by chromatographic methods. Blood phenazepam concentrations are typically less than 30 μg/L during therapeutic usage, but have frequently been in the 100-600 μg/L range in automotive vehicle operators arrested for impaired driving ability.[10]

Legal status

China

As of October 2015, phenazepam is a controlled substance in China.[11]

United States

Under federal United States law, phenazepam is not currently classified as a controlled substance, as the Federal Analog Act only provides for automatic assumed classification of chemicals "substantially similar" to existing Schedule I or Schedule II drugs, whereas all controlled benzodiazepines under the Controlled Substances Act are classified as Schedule IV. Although phenazepam is currently not controlled, sale for human use remains illegal in the United States.[12] Suppliers attempt to circumvent this regulation by placing a "Not for human use" disclaimer on the product's label.

Individual states in the United States often ban these analog drugs by name as they appear. Since 2012, Louisiana has classified phenazepam as a controlled dangerous substance.[13] This ban affects several products, some of which were sold at retail stores under the guise of air freshener or similar, containing phenazepam yet claiming not to be for human use. This legislation was introduced after one such product, branded as "Zannie" and marketed as an air freshener rapidly gained publicity as the subject of numerous media reports, attracting the attention of officials.[citation needed] The ensuing investigation effort, led by Senator Fred Mills and Louisiana Poison Center Director Mark Ryan, positively identified the active ingredient of "Zannie" as phenazepam. According to Ryan, chemical analysis identified the active ingredient as "100 percent phenazepam".[13]

Paul Halverson, director and state health officer for the Arkansas Department of Health, approved an emergency rule to ban the sale and distribution of phenazepam shortly after the Louisiana ban. The actions in Louisiana and Arkansas add this drug as a Schedule I Controlled Substance, meaning it has no approved medical use in the United States and has a high potential for abuse.

United Kingdom

Phenazepam is a class C drug in the UK.[14]

The UK home office banned importation of phenazepam on Friday 22 July 2011[15] while it drafted legislation, released in January 2012[16] to become law at the end of March 2012.[17] The bill was quashed following advice from the ACMD as it included two non-abusable steroids.[18] There was a new discussion about its fate on April 23, 2012, where it was decided that the bill would be rewritten and phenazepam would still be banned.[19]

It was eventually banned on June 13, 2012 as a class C, schedule II drug.[20]

Elsewhere

Phenazepam was classified as a narcotic in Finland in July, 2014.[21]

Phenazepam is considered a narcotic in Norway, as per a March 23, 2010 Health Department addition to the Regular Narcotic List.

In Russia, while the drug is considered a prescription medication (but not a controlled one, as all other benzodiazepines), some pharmacies sell it without prescriptions required.

In Canada, phenazepam is approved for laboratory studies,[citation needed] and is not scheduled.

In Estonia, phenazepam is a Schedule IV substance under the Narcotic Drugs and Psychotropic Substances Act.[citation needed] Schedule IV is the lowest classification of psychoactive substances in Estonia. It includes prescribable drugs, including other benzodiazpines.

Brand names

RU:

  • «Феназепам« (Phenazepam) tablets 0.5, 1 and 2.5 mg, solution for intramuscular and intravenous injection 1 mg/mL (0.1%)
  • «Элзепам» (Elzepam) tablets 0.5 and 1 mg, solution for intramuscular and intravenous injection 1 mg/mL (0.1%)
  • «Фензитат» (Phenzitat) tablets 0.5 and 1 mg
  • «Фенорелаксан» (Phenorelaxan) tablets 0.5 and 1 mg, solution for intramuscular and intravenous injection 1 mg/mL (0.1%)
  • «Транквезипам» (Trankvezipam) tablets 0.5 and 1 mg, solution for intramuscular and intravenous injection 1 mg/mL (0.1%)
  • «Фезипам» (Phezipam) tablets 0.5 and 1 mg (not to be confused with «Фезам» (Phezam) which contains cinnarizine/vinpocetine)
  • «Фезанеф» (Phezanef) tablets 1 mg[22]

See also

References

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  10. ↑ R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 9th edition, Biomedical Publications, Seal Beach, CA, 2011, pp. 1320-1321.
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