Promegestone

Promegestone
Systematic (IUPAC) name
	(8S,13S,14S,17S)-13,17-dimethyl-17-propionyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
Identifiers
CAS Number	34184-77-5
ATC code	G03DB07 (WHO)
PubChem	CID: 36709
ChemSpider	33716
Synonyms	R-5020; RU-5020
Chemical data
Formula	C22H30O2
Molecular mass	326.472 g/mol
	SMILES CCC(=O)[C@]1(CC[C@@H]2[C@@]1(CCC3=C4CCC(=O)C=C4CC[C@@H]23)C)C ;
	InChI InChI=1S/C22H30O2/c1-4-20(24)22(3)12-10-19-18-7-5-14-13-15(23)6-8-16(14)17(18)9-11-21(19,22)2/h13,18-19H,4-12H2,1-3H3/t18-,19+,21+,22-/m1/s1 ; Key:QFFCYTLOTYIJMR-XMGTWHOFSA-N ;

Promegestone (INN) (brand name Surgestone), also known as 17α,21-dimethyl-19-nor-Δ⁴,⁹-pregnadiene-3,20-dione, is a 19-norprogesterone derivative and steroidal progestin which was introduced in 1983 and is marketed in France, Portugal, and Argentina.^[1]^[2]^[3]^[4] Indications include gynaecological conditions caused by luteal insufficiency, including premenopausal disorders, dysmenorrhea, and premenstrual syndrome.^[4] Unlike some other progestins, promegestone is devoid of androgenic properties.^[4]

In addition to its progestogenic properties, promegestone has also been found to act as a non-competitive antagonist of the nicotinic acetylcholine receptor.^[5]

References

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