Prostaglandin EP3 receptor
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Prostaglandin E2 receptor 3 (EP3) is a prostaglandin receptor, encoded by the PTGER3 gene.[1]
Receptor
The receptor is a member of the G-protein coupled receptor family. It works through the G protein Gi, leading to a decrease in cytosolic cyclic AMP (cAMP). It is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions.
Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.
Variations
Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.[1]
See also
- Prostaglandin E2 receptor 1 (EP1)
- Prostaglandin E2 receptor 2 (EP2)
- Prostaglandin E2 receptor 4 (EP4)
- Eicosanoid receptor
References
External links
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
