Prosultiamine

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Prosultiamine
Skeletal formula of prosultiamine
Ball-and-stick model of the prosultiamine molecule
Systematic (IUPAC) name
N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(1E)-4-hydroxy-1-methyl-2-(propyldisulfanyl)but-1-en-1-yl]formamide
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
  • ℞ (Prescription only)
Routes of
administration		 Oral
Identifiers
CAS Number 59-58-5
ATC code None
PubChem CID: 5355019
ChemSpider 4511078
UNII UI32MM3XE3 YesY
Chemical data
Formula C15H24N4O2S2
Molecular mass 356.51 g/mol
  • O=CN(\C(=C(\SSCCC)CCO)C)Cc1cnc(nc1N)C

Prosultiamine (Alinamin, Binova, Jubedel, Taketron, Thiobeta, Thiotiamina), also known as thiamine propyl disulfide (TPD), is a disulfide thiamine derivative developed in Japan in the 1950s as a treatment for vitamin B1 deficiency.[1][2] It has improved lipid solubility relative to thiamine and is not rate-limited by dependency on intestinal transporters for absorption, hence the reasoning for its development.[3][4] It is also a potential treatment for HTLV, since it has been shown to reduce viral load and symptoms.[5]

See also

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Nervous System Disease: A New Outlet for an Old Drug?


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