R-type calcium channel

From Infogalactic: the planetary knowledge core
Jump to: navigation, search

<templatestyles src="Module:Infobox/styles.css"></templatestyles>

Calcium channel, voltage-dependent, R type, alpha 1E subunit
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CACNA1E ; BII; CACH6; CACNL1A6; Cav2.3
External IDs OMIM601013 MGI106217 HomoloGene20185 IUPHAR: 534 ChEMBL: 1687682 GeneCards: CACNA1E Gene
Orthologs
Species Human Mouse
Entrez 777 12290
Ensembl ENSG00000198216 ENSMUSG00000004110
UniProt Q15878 Q61290
RefSeq (mRNA) NM_000721 NM_009782
RefSeq (protein) NP_000712 NP_033912
Location (UCSC) Chr 1:
181.41 – 181.81 Mb
Chr 1:
154.39 – 154.88 Mb
PubMed search [1] [2]

The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms the pore through which calcium enters the cell and determines most of the channel's properties. This α1 subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 which in humans is encoded by the CACNA1E gene.[1][2][3] They are strongly expressed in cortex, hippocampus, striatum, amygdala and interpeduncular nucleus. [4]

They are poorly understood, but like Q-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics.

References

  1. Lua error in package.lua at line 80: module 'strict' not found.
  2. Lua error in package.lua at line 80: module 'strict' not found.
  3. Lua error in package.lua at line 80: module 'strict' not found.
  4. Lua error in package.lua at line 80: module 'strict' not found.

Further reading

  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.

External links