Roxatidine acetate
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Systematic (IUPAC) name | |
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2-oxo-2-(3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino)ethyl acetate
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Clinical data | |
Routes of administration |
Oral |
Pharmacokinetic data | |
Bioavailability | 80–90% |
Protein binding | 5–7% |
Metabolism | Hepatic deacetylation Minor involvement of CYP2D6 and CYP2A6 |
Biological half-life | 5–7 hours |
Excretion | Renal |
Identifiers | |
CAS Number | 78628-28-1 |
ATC code | A02BA06 (WHO) |
PubChem | CID: 5105 |
DrugBank | DB08806 |
ChemSpider | 4926 |
UNII | IV9VHT3YUM |
KEGG | D08495 |
ChEMBL | CHEMBL46102 |
Chemical data | |
Formula | C19H28N2O4 |
Molecular mass | 348.437 g/mol |
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Roxatidine acetate is a specific and competitive histamine H2 receptor antagonist drug that is used to treat gastric ulcers, Zollinger–Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis.[1][2]
Pharmacodynamic studies showed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion, and that a single bedtime dose of 150 mg was more effective than a dose of 75 mg twice daily in terms of inhibiting nocturnal acid secretion.[1]
It is available in countries including China, Japan, Korea, Germany, Italy, the Netherlands, Greece and South Africa.[2]
References
- ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 2.0 2.1 BioSpectrum Bureau 1 November 2012 Sinhuan's generic heart drug gets production approval
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