Secretoneurin

Secretogranin II
Identifiers
Symbols	SCG2 ; CHGC; EM66; SN; SgII
External IDs	OMIM: 118930 MGI: 103033 HomoloGene: 2591 GeneCards: SCG2 Gene
Gene ontology Molecular function • cytokine activity • protein binding • chemoattractant activity Cellular component • extracellular space • secretory granule Biological process • MAPK cascade • angiogenesis • negative regulation of endothelial cell proliferation • positive regulation of endothelial cell proliferation • inflammatory response • protein secretion • intracellular signal transduction • endothelial cell migration • eosinophil chemotaxis • positive chemotaxis • induction of positive chemotaxis • negative regulation of endothelial cell apoptotic process • negative regulation of extrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7857	20254
Ensembl	ENSG00000171951	ENSMUSG00000050711
UniProt	P13521	Q03517
RefSeq (mRNA)	NM_003469	NM_009129
RefSeq (protein)	NP_003460	NP_033155
Location (UCSC)	Chr 2: 223.6 – 223.6 Mb	Chr 1: 79.43 – 79.44 Mb
PubMed search	[1]	[2]

Secretoneurin, is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC).

Secretoneurin is involved in chemotaxis of monocytes and eosinophils (comparable in potency to IL8) and endothelial cells and in regulation of endothelial cell proliferation. Highest secretoneurin levels are found in anterior pituitary, followed by adrenal medulla and posterior pituitary hypothalamus (2- to 6-fold lower levels in other brain regions investigated). Secretoneurin has been shown to have potent angiogenic activity in vivo in mouse cornea model and in vitro in a 3-dimensional gel. Secretoneurin also stimulates dopamine release from the central striatal neurons and basal ganglia.

Signaling

PI3 kinase, phosphodiesterase and phospholipase D inhibition inhibits its pro-migration effects, but blocking PKC and tyrosine kinases has not been shown to have effect. Downstream to these ERK type MAP kinase and AKT are activated.

External links

• secretoneurin at the US National Library of Medicine Medical Subject Headings (MeSH)