Glucagon-like peptide-1 agonist
Glucagon-like peptide-1 receptor agonists also known as GLP-1 receptor agonists or incretin mimetics are agonists of the GLP-1 receptor. This class of drugs is used for the treatment of type 2 diabetes.[1] One of their advantages over older insulin secretagogues, such as sulfonylureas or meglitinides, is that they have a lower risk of causing hypoglycemia.[2]
There is some concern over the safety profile of these drugs due to proliferative effects in the pancreas.[3]
Approved GLP-1 agonists:
- exenatide (Byetta/Bydureon), approved in 2005/2012
- liraglutide (Victoza, Saxenda), approved 2010[4]
- lixisenatide (Lyxumia), approved in EU 2013[5]
- albiglutide (Tanzeum), approved in 2014 by GSK[6]
- dulaglutide (Trulicity), approved in 2014 - manufactured by Eli Lily K[7]
Under investigation: [1]
- taspoglutide, phase III halted Sept 2010,
These agents work in the same pathway as DPP-4 inhibitors but are generally considered more potent.[8]
References
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