Strabismus (protein)
| vang-like 1 (van gogh, Drosophila) | |
|---|---|
| Identifiers | |
| Symbol | VANGL1 |
| Entrez | 81839 |
| OMIM | 610132 |
Strabismus was originally identified as a Drosophila protein involved in planar cell polarity.[1] Flies with mutated strabismus genes have altered development of ommatidia in their eyes. Vertebrates have two Strabismus-related proteins, VANGL1 and VANGL2 (an alternate name for the Drosophila "Strabismus" protein is "Van Gogh").
The amino acid sequence and localization studies for Strabismus indicate that it is a membrane protein. Prickle is another protein in the planar cell polarity signaling pathway. Prickle is recruited to the cell surface membrane by strabismus.[2] In cells of the developing Drosophila wing, Prickle and Strabismus are concentrated at the cell surface membrane on the most proximal side of cells.[3]
Vertebrate cell movement
| vang-like 2 (van gogh, Drosophila) | |
|---|---|
| Identifiers | |
| Symbol | VANGL2 |
| Entrez | 57216 |
| OMIM | 600533 |
VANGL2 is involved in the migration of groups of cells during vertebrate embryogenesis.[4]
Humans
In humans, mutations in VANGL1 have been associated with neural tube defects including spina bifida,[5] and with some forms of cancer including hepatocellular carcinoma.[6][7]
References
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