Striosome
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(Redirected from Striosomes)
| Striosome | |
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| Identifiers | |
| NeuroLex ID | Striosome |
| TA | Lua error in Module:Wikidata at line 744: attempt to index field 'wikibase' (a nil value). |
| TH | {{#property:P1694}} |
| TE | {{#property:P1693}} |
| FMA | {{#property:P1402}} |
| Anatomical terms of neuroanatomy
[[[d:Lua error in Module:Wikidata at line 863: attempt to index field 'wikibase' (a nil value).|edit on Wikidata]]]
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The striosomes (also referred to as the striatal patches) are one of two complementary chemical compartments within the striatum (the other compartment is known as the matrix) that can be visualized by staining for immunocytochemical markers such as acetylcholinesterase,[1] enkephalin, substance P, limbic system-associated membrane protein (LAMP),[2] AMPA receptor subunit 1 (GluR1),[3] dopamine receptor subunits, and calcium binding proteins.[4] Striosomal abnormalities have been associated with neurological disorders, such as mood dysfunction in Huntington's disease,[5] though their precise function remains unknown. Striosomes were discovered by Ann Graybiel in 1978 using acetylcholinesterase histochemistry.
File:Matrix Striosomes mar5.jpg
Matrix and Striosome Compartments: Fluorescence microscopy image of a coronal mouse brain section, cut through the striatum (caudate putamen, CP). The matrix/striosome division is here revealed by dual immunohistochemical (calbindin, CALB; green) and transgenic (red fluorescent protein, RFP; red) labeling of the matrix compartment, using the matrix-specific Cre-mouse line Gpr101-Cre.[6] Unlabeled patches constitute striosomes.
References
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