TMOD2

Tropomodulin 2 (neuronal)
Identifiers
Symbols	TMOD2 ; N-TMOD; NTMOD
External IDs	OMIM: 602928 MGI: 1355335 HomoloGene: 22817 GeneCards: TMOD2 Gene
Gene ontology Molecular function • actin binding • tropomyosin binding Cellular component • cytoskeleton • striated muscle thin filament • myofibril • growth cone Biological process • muscle contraction • actin filament organization • neuron-neuron synaptic transmission • nervous system development • learning or memory • myofibril assembly • positive regulation of G-protein coupled receptor protein signaling pathway • pointed-end actin filament capping Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	29767	50876
Ensembl	ENSG00000128872	ENSMUSG00000032186
UniProt	Q9NZR1	Q9JKK7
RefSeq (mRNA)	NM_001142885	NM_001038710
RefSeq (protein)	NP_001136357	NP_001033799
Location (UCSC)	Chr 15: 51.75 – 51.82 Mb	Chr 9: 75.57 – 75.61 Mb
PubMed search	[1]	[2]

Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.

Function

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.