Tetrazolylglycine

From Infogalactic: the planetary knowledge core
Jump to: navigation, search
Tetrazolylglycine
1 : 1 mixture (racemate)
Names
IUPAC name
(RS)-amino(1H-tetrazol-5-yl)acetic acid
Identifiers
138199-51-6
ChEMBL ChEMBL140784 YesY
ChemSpider 112321 YesY
4068
Jmol 3D model Interactive image
PubChem 126383
  • InChI=1S/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8) YesY
    Key: UKBRUIZWQZHXFL-UHFFFAOYSA-N YesY
  • InChI=1/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8)
    Key: UKBRUIZWQZHXFL-UHFFFAOYAB
  • O=C(O)C(N)c1nnnn1
Properties
C3H5N5O2
Molar mass 143.104
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references

Tetrazolylglycine (Tet-Gly, LY-285,265) is a potent and selective NMDA receptor agonist, stimulating the NMDA receptor with higher potency than either glutamate or NMDA.[1] It is a potent convulsant and excitotoxin and is used in scientific research.[2][3]

References

  1. ↑ Lunn WH, Schoepp DD, Calligaro DO, Vasileff RT, Heinz LJ, Salhoff CR, O'Malley PJ. DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy. Journal of Medicinal Chemistry. 1992 Nov 27;35(24):4608-12. PMID 1361579
  2. ↑ Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. European Journal of Pharmacology. 1991 Oct 15;203(2):237-43. PMID 1686860
  3. ↑ Schoepp DD, Lunn WH, Salhoff CR, McDonald JW. The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin. European Journal of Pharmacology. 1994 Jan 3;270(1):67-72. PMID 8157082



<templatestyles src="Asbox/styles.css"></templatestyles>

Stub icon

This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.
Retrieved from "https://infogalactic.com/w/index.php?title=Tetrazolylglycine&oldid=5187002"