Thiamylal
From Infogalactic: the planetary knowledge core
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| Systematic (IUPAC) name | |
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5-Allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
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| AHFS/Drugs.com | International Drug Names |
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| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Biological half-life | 14.3 h (cats) |
| Identifiers | |
| CAS Number | 77-27-0  |
| ATCvet code | QN01AF90 (WHO) |
| PubChem | CID: 3032285 |
| IUPHAR/BPS | 7305 |
| DrugBank | DB01154 |
| ChemSpider | 2297298 |
| UNII | 01T23W89FR |
| KEGG | D06106 |
| ChEBI | CHEBI:9536 |
| ChEMBL | CHEMBL440 |
| Synonyms | Thiamylal, Thioseconal, Surital |
| Chemical data | |
| Formula | C12H18N2O2S |
| Molecular mass | 254.35 g/mol |
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Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant, and hypnotic effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in surgical anaesthesia [1] or as an anticonvulsant to counteract side effects from other anaesthetics.[2] It is the thiobarbiturate analogue of secobarbital.
References
- ↑ Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300.
- ↑ Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100.
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