Tiletamine

From Infogalactic: the planetary knowledge core
Jump to: navigation, search
Tiletamine
Tiletamine.svg
Systematic (IUPAC) name
2-ethylamino-2-(2-thienyl) cyclohexanone
Clinical data
AHFS/Drugs.com International Drug Names
Legal status
Routes of
administration
IV, IM, SC, Other
Pharmacokinetic data
Metabolism Liver
Excretion Kidneys
Identifiers
CAS Number 14176-50-2 N
ATC code none
PubChem CID: 26533
ChemSpider 24714 YesY
UNII 2YFC543249 YesY
KEGG D08596 YesY
Chemical data
Formula C12H17NOS
Molecular mass 223.34 g/mol
 NYesY (what is this?)  (verify)

Tiletamine is a dissociative anesthetic and pharmacologically classified as an NMDA receptor antagonist.[1] It is related chemically to ketamine.[2] Tiletamine hydrochloride exists as odourless white crystals.

It is used in veterinary medicine in the compound product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs.[3][4][5] It is sometimes used in combination with xylazine (Rompun) to tranquilize large mammals such as polar bears[6] and wood bison.[7] Telazol is the only commercially available tiletamine product in the United States. It is contraindicated in patients of an ASA score of III or greater and in animals with CNS signs, hyperthyroidism, cardiac disease, pancreatic or renal disease, pregnancy, glaucoma, or penetrating eye injuries.[3]

Abuse of Telazol has been documented.[8] Animal studies have also shown that tiletamine produces rewarding and reinforcing effects.[9] Tiletamine products are classified as Schedule III controlled substances in the United States.[10]

See also

References

  1. Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  2. NIH Pubchem entry for Tiletamine
  3. 3.0 3.1 "Tiletamine entry at Drugs.com". Retrieved 5 January 2012.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  4. Lin HC, Thurmon JC, Benson GJ, Tranquilli WJ. Telazol: a review of its pharmacology and use in veterinary medicine. J Vet Pharmacol Ther. 1993 Dec;16(4):383-418. Review. PMID 8126757
  5. NIH Tiletamine entry in Toxnet Page last reviewed 1/21/2009
  6. Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  7. Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  8. Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  9. Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  10. "Lists of: Scheduling Actions, Controlled Substances, Regulated Chemicals" (PDF). Drug Enforcement Administration. Retrieved 5 January 2012.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>

External links