Tofenacin

Tofenacin

Systematic (IUPAC) name
N-methyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine
Clinical data
Legal status	℞ (Prescription only)
Identifiers
CAS Number	15301-93-6 10488-36-5 (HCl)
ATC code	None
PubChem	CID: 25315
ChemSpider	23647
Chemical data
Formula	C17H21NO
Molecular mass	255.355 g/mol
SMILES O(CCNC)C(c1ccccc1)c2ccccc2C
InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)17(19-13-12-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3 Key:PNYKGCPSFKLFKA-UHFFFAOYSA-N

Tofenacin (INN; Elamol, Tofacine, Tofalin), or tofenacin hydrochloride (USAN), also sometimes called mono-N-desmethylorphenadrine, is an antidepressant drug with a tricyclic-like structure which was developed and marketed in the United Kingdom and Italy in 1971 and 1981, respectively, by Brocades-Stheeman & Pharmacia (now part of Astellas Pharma). It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. In addition to its use as a pharmaceutical medication, tofenacin is the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients.

See also

• Orphenadrine
• Clemastine