Tropomodulin
Lua error in package.lua at line 80: module 'strict' not found. Tropomodulin is a protein which binds and caps the minus end of actin (the "pointed" end), regulating the length of actin filaments in muscle and non-muscle cells. The protein functions by physically blocking the spontaneous dissociation of ADP-bound actin monomers from the minus end of the actin fibre. This, along with plus end capping proteins, such as capZ stabilise the structure of the actin filament. End capping is particularly important when long-lived actin filaments are necessary, for example: in myofibrils. Inhibition of tropomodulin capping activity leads to dramatic increase in thin filament length from its pointed end.[1][2]
Genes
References
External links
- Tropomodulin at the US National Library of Medicine Medical Subject Headings (MeSH)
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