URB597

URB597

Names
IUPAC name [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate
Identifiers
CAS Number	546141-08-6 N
ChEMBL	ChEMBL184238 Y
ChemSpider	1156960 Y
IUPHAR/BPS	4339
Jmol 3D model	Interactive image
MeSH	URB597
PubChem	1383884
InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24) Y Key: ROFVXGGUISEHAM-UHFFFAOYSA-N Y InChI=1/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24) Key: ROFVXGGUISEHAM-UHFFFAOYAO
SMILES O=C(NC1CCCCC1)OC2=CC=CC(C3=CC=CC(C(N)=O)=C3)=C2
Properties
Chemical formula	C20H22N2O3
Molar mass	338.4 g/mol
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

URB597 is a relatively selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH). FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. In pre-clinical laboratory tests researchers found URB597 increased the production of endocannabinoids resulting in measurable antidepressant and analgesic effects.

URB597 is also known as KDS-4103. KDS-4103 is being developed by Kadmus Pharmaceuticals, Inc. for clinical trials in humans. Kadmus claims, on their website (linked below) that this class of compounds may have antidepressant, anti-anxiety, and pain-killing effects.

See also

• FAAH
• 4-Nonylphenylboronic acid
• LY-2183240
• PF-04457845

External links

• Kadmus Pharmaceuticals official website
• Modulation of anxiety through blockade of anandamide hydrolysis in Nature
• New drug acts as marijuana in the brain at cannabis.net