Vedaclidine

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Vedaclidine
File:Vedaclidine.png
Systematic (IUPAC) name
(3-(3-1-Butylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[2.2.2]octane
Identifiers
CAS Number 141575-52-2
ATC code None
PubChem CID: 60868
ChemSpider 54852
UNII 98IW5HAV1N YesY
Chemical data
Formula C13H21N3S2
Molecular mass 283.455 g/mol
  • C3CC1CCN3CC1c2nsnc2SCCCC

Vedaclidine (LY-297,802, NNC 11-1053) is a novel analgesic drug which acts as a mixed agonist–antagonist at muscarinic acetylcholine receptors, being a potent and selective agonist for the M1 and M4 subtypes, yet an antagonist at the M2, M3 and M5 subtypes.[1][2] It is orally active and an effective analgesic over 3x the potency of morphine, with side effects such as salivation and tremor only occurring at many times the effective analgesic dose.[3][4][5] Human trials showed little potential for development of dependence or abuse,[6] and research is continuing into possible clinical application in the treatment of neuropathic pain and cancer pain relief.[7]

See also

References

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