ZC3HC1

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Lua error in package.lua at line 80: module 'strict' not found. Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Nuclear-interacting partner of ALK is a protein that in humans is encoded by the ZC3HC1 gene.[1][2]


Model organisms

Model organisms have been used in the study of ZC3HC1 function. A conditional knockout mouse line, called Zc3hc1tm1a(KOMP)Wtsi[16][17] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[18][19][20]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[14][21] Twenty two tests were carried out on mutant mice and eleven significant abnormalities were observed.[14] Fewer than expected homozygous mutant mice were identified at weaning. Mutants appear to be subfertile, had decreased vertical activity in an open field, decreased lean body mass, decreased rib number and decreased mature B cell number. Males also had a decreased body weight, an abnormal posture and atypical indirect calorimetry data. Females also had an abnormally short snout and atypical haematology parameters .[14]

References

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  14. 14.0 14.1 14.2 14.3 Lua error in package.lua at line 80: module 'strict' not found.
  15. Mouse Resources Portal, Wellcome Trust Sanger Institute.
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Further reading

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