3-Iodothyronamine

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3-Iodothyronamine
Skeletal formula of the 3-iodothyronamine
Ball-and-stick model of the 3-iodothyronamine molecule
Names
IUPAC name
4-[4-(2-Amino-ethyl)-2-iodo-phenoxy]-phenol
Other names
T1AM
Identifiers
712349-95-6 N
ChemSpider 8126125 YesY
Jmol 3D model Interactive image
Interactive image
PubChem 9950514
  • InChI=1S/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2 YesY
    Key: XIINYOJWNGOUPF-UHFFFAOYSA-N YesY
  • InChI=1/C14H14INO2/c15-13-9-10(7-8-16)1-6-14(13)18-12-4-2-11(17)3-5-12/h1-6,9,17H,7-8,16H2
    Key: XIINYOJWNGOUPF-UHFFFAOYAJ
  • OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1
  • Ic2cc(ccc2Oc1ccc(O)cc1)CCN
Properties
C14H14INO2
Molar mass 355.17 g/mol
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

3-Iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a recently discovered G protein-coupled receptor.[1][2] T1AM is the most potent endogenous TAAR1 agonist yet discovered.[3] Activation of TAAR1 by T1AM results in the production of large amounts of cAMP. This effect is coupled with decreased body temperature and cardiac output.[4] Wu et al. have pointed out that this relationship is not typical of the endocrine system, indicating that TAAR1 activity may not be coupled to G-proteins in some tissues, or that T1AM may interact with other receptor subtypes.[3]

T1AM may be part of a signaling pathway to modulate cardiac function, as the compound can induce negative inotropic effects and decrease cardiac output.[5]

See also

External links

References

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