5'-Guanidinonaltrindole
From Infogalactic: the planetary knowledge core
Systematic (IUPAC) name | |
---|---|
5'-Guanidinyl-17-(cyclopropylmethyl)-6,7-dehydro-4,5α-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan
|
|
Identifiers | |
PubChem | CID: 6604846 |
IUPHAR/BPS | 1669 |
ChemSpider | 21259050 |
ChEMBL | CHEMBL330427 |
Synonyms | 5'-Guanidinonaltrindole, GNTI |
Chemical data | |
Formula | C27H29N5O3 |
Molecular mass | 471.550 g/mol |
|
|
|
|
(what is this?) (verify) |
5'-Guanidinonaltrindole (5'-GNTI) is an opioid antagonist used in scientific research which is highly selective for the κ opioid receptor. It is 5x more potent and 500 times more selective than the commonly used κ-opioid antagonist norbinaltorphimine.[1] It has a slow onset and long duration of action,[2][3] and produces antidepressant effects in animal studies.[4] It also increases allodynia by interfering with the action of the κ-opioid peptide dynorphin.[5]
See also
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
<templatestyles src="Asbox/styles.css"></templatestyles>
Categories:
- Chemical articles having calculated molecular weight overwritten
- Articles with changed InChI identifier
- Infobox drug articles without a structure image
- Chemical articles without CAS Registry Number
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without UNII source
- Drugboxes with an unspecified ATC code
- Drugs with no legal status
- Semisynthetic opioids
- Opioid antagonists
- Guanidines
- Indolomorphinans
- Phenols
- Alcohols
- Kappa antagonists
- Irreversible receptor antagonists
- Nervous system drug stubs