6-Fluoronorepinephrine

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6-Fluoronorepinephrine
6-Fluoronorepinephrine.png
Systematic (IUPAC) name
4-(2-amino-1-hydroxy-ethyl)-5-fluoro-benzene-1,2-diol
Clinical data
Legal status
  • Uncontrolled
Identifiers
CAS Number 86820-21-5 N
ATC code none
PubChem CID: 1862
IUPHAR/BPS 510
ChemSpider 1792 YesY
ChEMBL CHEMBL281232 YesY
Chemical data
Formula C8H10FNO3
Molecular mass 187.17 g/mol
  • Fc1cc(O)c(O)cc1C(O)CN
  • InChI=1S/C8H10FNO3/c9-5-2-7(12)6(11)1-4(5)8(13)3-10/h1-2,8,11-13H,3,10H2 YesY
  • Key:SBUQBFTXTZSRMH-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

6-Fluoronorepinephrine (6-FNE) is a selective α1- and α2-adrenergic receptor full agonist related to norepinephrine.[1][2] It is the only selective full agonist for the α-adrenergic receptors known to date and has been used to study their function in scientific research.[2] Infusion of 6-FNE into the locus coeruleus of rodents produces marked hyperactivity and behavioral disinhibition by suppressing activity in the area via stimulation of α1-adrenergic receptors.[2][3]

References

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