AB-005

AB-005

Systematic (IUPAC) name
[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone
Clinical data
Legal status	CA: Schedule II
Identifiers
CAS Number	895155-25-6
PubChem	CID: 11537652
ChemSpider	9712433
ChEMBL	CHEMBL571330
Chemical data
Formula	C23H32N2O
Molecular mass	352.51 g/mol
SMILES CC1(C(C1(C)C)C(=O)C2=CN(C3=CC=CC=C32)CC4CCCCN4C)C
InChI InChI=1S/C23H32N2O/c1-22(2)21(23(22,3)4)20(26)18-15-25(19-12-7-6-11-17(18)19)14-16-10-8-9-13-24(16)5/h6-7,11-12,15-16,21H,8-10,13-14H2,1-5H3 Key:MOBWRRIAIHYXLB-UHFFFAOYSA-N

AB-005 or [1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone is a designer drug offered by online vendors as a cannabimimetic agent. The structure and pharmacological activity of AB-005 was published in 2010, prior to its commercial availability in 2012, where it was reported to have high affinity for both CB1 (K_i = 5.5 nM) and CB2 receptors (K_i = 0.48 nM). AB-005 features groups found in other previously reported synthetic cannabinoids: the tetramethylcyclopropane group of UR-144 and XLR-11 as well as the (1-methyl-2-piperidinyl)methyl substituent of AM-1248 and AM-1220. No information regarding the in vivo activity of AB-005 has been published, and only anecdotal reports are known of its psychoactivity in humans.

Legal status

Psychoactive products in New Zealand containing this drug have been given interim approval under recent psychoactive substances legislation.

See also

• A-834,735
• AB-001
• AM-1248
• AM-1220
• JWH-018
• FUB-144
• UR-144
• XLR-11