ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Identifiers
Symbols	ABCC9 ; ABC37; ATFB12; CANTU; CMD1O; SUR2
External IDs	OMIM: 601439 MGI: 1352630 HomoloGene: 56521 IUPHAR: 2746 ChEMBL: 1971 GeneCards: ABCC9 Gene
Gene ontology Molecular function • transporter activity • potassium channel activity • ATP binding • sulfonylurea receptor activity • potassium channel regulator activity • ATPase activity, coupled to transmembrane movement of substances • ion channel binding Cellular component • plasma membrane • voltage-gated potassium channel complex • ATP-sensitive potassium channel complex • sarcomere • sarcolemma Biological process • potassium ion transport • signal transduction • synaptic transmission • metabolic process • potassium ion import • defense response to virus • transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10060	20928
Ensembl	ENSG00000069431	ENSMUSG00000030249
UniProt	O60706	P70170
RefSeq (mRNA)	NM_005691	NM_001044720
RefSeq (protein)	NP_005682	NP_001038185
Location (UCSC)	Chr 12: 21.8 – 21.94 Mb	Chr 6: 142.59 – 142.7 Mb
PubMed search	[1]	[2]

ATP-binding cassette, sub-family C member 9 (ABCC9) also known as sulfonylurea receptor 2 (SUR2) is an ATP-binding cassette transporter that in humans is encoded by the ABCC9 gene.

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion.

• SUR2A — uses exon 38A
• SUR2B — uses exon 38B
• SUR-delta-14 — lack exon 14 and uses exon 38A

Clinical significance

The gene has been associated with dilated cardiomyopathy and Cantú syndrome.

A variant has also been associated with circa 25 minutes more sleep per day in humans; lack thereof has been associated with three hours less sleep per day in fruit flies.

See also

• Sulfonylurea receptor

External links

• ABCC9 human gene location in the UCSC Genome Browser.
• ABCC9 human gene details in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.