AM-1248
Systematic (IUPAC) name | |
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1-[(N-methylpiperidin-2-yl)methyl]-3-(adamant-1-oyl)indole
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Clinical data | |
Legal status |
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Identifiers | |
CAS Number | 335160-66-2 |
PubChem | CID: 10293794 |
ChemSpider | 8469262 |
UNII | 5EX9HEF4HK |
Chemical data | |
Formula | C26H34N2O |
Molecular mass | 390.561 g/mol |
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AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors CB1 and CB2, but with some dispute between sources over its exact potency and selectivity. Replacing the 3-(1-naphthoyl) group found in many indole derived cannabinoid ligands, with an adamantoyl group, generally confers significant CB2 selectivity,[1] but reasonable CB1 affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl substitution is used at the indole 1-position.[2][3] The related compound 1-pentyl-3-(1-adamantoyl)indole was identified as having been sold as a cannabinoid designer drug in Hungary in 2011, along with another synthetic cannabinoid AM-679.[4]
Legality
Sweden's public health agency suggested to classify AM-1248 as hazardous substance on June 1, 2015.[5]
As of October 2015 AM-1248 is a controlled substance in China.[6]
See also
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ US patent 7820144, Makriyannis A, Deng H, "Receptor selective cannabimimetic aminoalkylindoles", granted 2010-10-26
- ↑ WO patent 200128557, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted 2001-06-07
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
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- Cannabinoids
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