Ajmalicine

Ajmalicine

Systematic (IUPAC) name
(19α)-16,17-didehydro- 19-methyloxayohimban- 16-carboxylic acid methyl ester
Clinical data
Legal status	℞ (Prescription only)
Routes of administration	Oral
Identifiers
CAS Number	483-04-5 N
ATC code	none
PubChem	CID: 251561
ChemSpider	390541 Y
ChEMBL	CHEMBL123325 Y
Chemical data
Formula	C21H24N2O3
Molecular mass	352.43 g/mol
SMILES O=C(OC)\C4=C\OC(C5CN3CCc1c(nc2ccccc12)C3CC45)C
InChI InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1 Y Key:GRTOGORTSDXSFK-XJTZBENFSA-N Y
NY (what is this?)  (verify)

Ajmalicine, also known as δ-yohimbine or raubasine, is an antihypertensive drug used in the treatment of high blood pressure. It has been marketed under numerous brand names including Card-Lamuran, Circolene, Cristanyl, Duxil, Duxor, Hydroxysarpon, Iskedyl, Isosarpan, Isquebral, Lamuran, Melanex, Raunatin, Saltucin Co, Salvalion, and Sarpan. It is also an alkaloid found naturally in various plants such as Rauwolfia spp., Catharanthus roseus, and Mitragyna speciosa.

Ajmalicine is structurally related to yohimbine, rauwolscine, and other yohimban derivatives. Like corynanthine, it acts as a α₁-adrenergic receptor antagonist with preferential actions over α₂-adrenergic receptors, underlying its hypotensive rather than hypertensive effects.

See also

• Corynanthine
• Rauwolscine
• Spegatrine
• Yohimbine