Alpha-3 beta-4 nicotinic receptor

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The alpha-3 beta-4 nicotinic receptor, also known as the α3β4 receptor, is a type of nicotinic acetylcholine receptor, consisting of α3 and β4 subunits.[1][2] It is located in the autonomic ganglia[3] and adrenal medulla,[4] where activation yields post- and/or presynaptic excitation.[2]

As with other nicotinic acetylcholine receptors, the α3β4 receptor is pentameric [(α3)m(β4)n where m + n = 5]. The exact subunit stoichiometry is not known and it is possible that more than one functional α3β4 receptor assembles in vivo with varying subunit stoichiometries.

Ligands

Agonists

Antagonists

Competitive

3d structure of "compound 5" (Zaveri 2010). Ki, 508 nM at α3β4 nAChR
  • compound 5, highly selective over α4β2 and α7[7]

Noncompetitive

See also

References

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