Anirvan Ghosh

Anirvan Ghosh অনির্বাণ ঘোষ
File:Anirvan Ghosh Durham 2007.jpg Anirvan Ghosh in Durham, 2007
Born	1964 Bloomington, Indiana, United States
Residence	California, United States
Nationality	American
Fields	Neuroscience
Institutions	University of California, San Diego, Johns Hopkins School of Medicine, Harvard Medical School, Stanford University, California Institute of Technology

Anirvan Ghosh (Bengali: অনির্বাণ ঘোষ) is an American neuroscientist of Indian descent. His research has contributed to our understanding of the molecular mechanisms that regulate development of the mammalian brain. A major focus of his research has been to identify mechanisms that regulate neuronal connectivity and the effects of neuronal activity on brain development. He is currently the Global Head of Neuroscience Discovery at F. Hoffmann-La Roche.

Biography

Anirvan Ghosh was born in 1964 in Bloomington, Indiana and grew up in Kanpur, India. After completing high school at Central School (Kendriya Vidyalaya) IIT Kanpur, he moved to the U.S. in 1981 to pursue his undergraduate education at the California Institute of Technology. He graduated with a B.S. with honors in Physics from Caltech in 1985. From 1985 to 1990 he was a graduate student in the Stanford University Neurosciences Graduate Program, where he worked on the role of subplate neurons in establishing cortical connections in the laboratory of Carla J. Shatz. He received his Ph.D. in Neurobiology from Stanford University in 1991. His postdoctoral training was with Michael E. Greenberg at Harvard Medical School where he worked on regulation of differentiation by extracellular signals and calcium regulation of BDNF expression. From 1995 to 2003 he was on the faculty in the Department of Neuroscience at the Johns Hopkins School of Medicine. While at Johns Hopkins he cloned CREST as a calcium-regulated transcription factor and showed that it plays a critical role in brain development. In 2003 he moved to UCSD as the Stephen Kuffler Professor in the Neurobiology Section of the Division of Biological Sciences. His laboratory investigates regulation of synaptic connectivity and neural circuit formation in the mammalian brain. Ghosh was named Global Head of Neuroscience Discovery at Roche in 2011.

Awards

• EJLB Foundation Scholar Research Award
• Damon Runyon Scholar Award
• Klingenstein Fellowship Award in Neuroscience
• Alfred P. Sloan Research Fellow
• Pew Scholar Award
• Society for Neuroscience Young Investigator Award
• Presidential Early Career Award for Scientists and Engineers (PECASE)
• UCSD Revelle College Outstanding Faculty Award

Major publications

• Ghosh, A., A. Antonini, S.K. McConnell and C.J. Shatz (1990). Requirement for subplate neurons in the formation of thalamocortical connections. Nature 347: 179-181
• Ghosh, A. and C.J. Shatz (1992). Involvement of subplate neurons in the formation of ocular dominance columns. Science 255:1441-1443.
• Ghosh, A., J. Carnahan and M.E. Greenberg (1994). Requirement for BDNF in activity-dependent survival of cortical neurons. Science 263:1618-1623.
• Ghosh, A. and M.E. Greenberg (1995). Distinct roles for bFGF and NT3 in the regulation of cortical neurogenesis. Neuron 15:89-103.
• Polleux, F., R.J. Giger, D.D. Ginty, A.L. Kolodkin, and A. Ghosh (1998). Patterning of cortical efferent projections by semaphorin-neuropilin interactions. Science 282:1904-1906.
• Polleux, F., T. Morrow and A. Ghosh (2000). Semaphorin 3A is a chemoattractant for developing cortical dendrites. Nature 404:567-573.
• Aizawa, H., Hu, S-C, Bobb, K., Balakrishnan, K., Ince, G., Gurevich, I., Cowan, M., and A. Ghosh (2004). Dendrite development regulated by CREST, a calcium-regulated transcription activator. Science 303:197-202.
• Qiu, Z. and A. Ghosh (2008) A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron 60:775-787.
• Sylwestrak, E and A. Ghosh (2012) Elfn1 regulates target-specific release probability at CA1-interneuron synapses. Science 338:536-540.

References

• Official page: Anirvan Ghosh, Professor of Biology, UCSD
• The Ghosh Lab
• Science Daily: Gene Essential For Development Of Normal Brain Connections Resulting From Sensory Input Discovered
• Science: Dendrite Development Regulated by CREST, a Calcium-Regulated Transcriptional Activator
• Johns Hopkins University Gazette: Heads up! The Brain Behind The Acclaim, by Michael Purdy
• Fundamental Neuroscience, Elsevier
• Directory of Pew Scholars