Anti-SSA/Ro autoantibodies

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File:SSA SSB ANA.jpg
Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC conjugate.

Anti-SSA autoantibodies (Anti-Sjögren’s-syndrome-related antigen A, also called anti-Ro, or the combination anti-SSA/Ro or anti Ro/SSA autoantibodies) are anti-nuclear autoantibodies that are associated with many autoimmune diseases, such as systemic lupus erythematosus (SLE), SS/SLE overlap syndrome, subacute cutaneous LE (SCLE), neonatal lupus and primary biliary cirrhosis.[1] Also, they are often present in Sjögren's syndrome.[2] [3]

Presence of Anti-SSA/Ro in pregnant women with SLE is associated with an increased risk of neonatal lupus erythematosus in the child.[4]

Ro protein binds to Y RNA

Epidemiology

Approximately only 0.1 to 0.5 percent of the general population has the antibody.[citation needed]

References

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  4. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. Page 160. ISBN 0-7216-2921-0.


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