BD1060

BD1060
Systematic (IUPAC) name
	N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine
Identifiers
CAS Number	138356-10-2
PubChem	CID: 9882367
ChemSpider	8058042
Chemical data
Formula	C14H20Cl2N2
Molecular mass	287.23 g/mol
	SMILES C1CCN(C1)CCNCCC2=CC(=C(C=C2)Cl)Cl ;
	InChI InChI=1S/C14H20Cl2N2/c15-13-4-3-12(11-14(13)16)5-6-17-7-10-18-8-1-2-9-18/h3-4,11,17H,1-2,5-10H2 ; Key:KFLJZQLENAVFAL-UHFFFAOYSA-N ;

BD1060 or N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of K_i = 3 ± 0.1 nM for the sigma-1 receptor and greater than 50 times selectivity over the sigma-2 receptor.^[1]

Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine.^[1]

References