Bacillary angiomatosis
| Bacillary angiomatosis | |
|---|---|
| Classification and external resources | |
| Specialty | Lua error in Module:Wikidata at line 446: attempt to index field 'wikibase' (a nil value). |
| ICD-10 | A44.8 (ILDS A44.85), B20.1 (ILDS B20.11) |
| ICD-9-CM | 088.0 |
| DiseasesDB | 2173 |
| eMedicine | derm/44 |
| Patient UK | Bacillary angiomatosis |
| MeSH | D016917 |
Bacillary angiomatosis (BA) is a form of angiomatosis associated with bacteria of the Bartonella genus.
Contents
Causes
It is caused by either Bartonella henselae or Bartonella quintana.[1]
- Bartonella henselae is most often transmitted through a cat scratch or bite,[2] though ticks and fleas may also act as a vector.
- Bartonella quintana is usually transmitted by lice.
It can manifest in people with AIDS[3] and rarely appears in those who are immunocompetent.[citation needed]
Presentation
BA is characterised by the proliferation of blood vessels, resulting in them forming tumour-like masses in the skin and other organs.
Symptoms
Cutaneous BA is characterised by the presence of lesions on or under the skin. Appearing in numbers from one to hundreds, these lesions may take several forms:
- papules or nodules which are red, globular and non-blanching, with a vascular appearance
- purplish nodules sufficiently similar to Kaposi's sarcoma that a biopsy may be required to verify which of the two it is
- a purplish lichenoid plaque
- a subcutaneous nodule which may have ulceration, similar to a bacterial abscess
While cutaneous BA is the most common form of BA, BA can also affect several other parts of the body, such as the brain, bone, bone marrow, lymph nodes, gastrointestinal tract, respiratory tract, spleen and liver. Symptoms vary depending on which parts of the body are affected; for example, those whose livers are affected may have an enlarged liver and fever, while those with osseous BA will experience intense pain in the affected area.
Treatment and prevention
While curable, BA is potentially fatal if not treated.
BA responds dramatically to several antibiotics. Usually, erythromycin will cause the skin lesions to gradually fade away in the next four weeks, resulting in complete recovery. Doxycycline may also be used. However, if the infection does not respond to either of these, the medication is usually changed to tetracycline. If the infection is serious, then a bactericidal medication may be coupled with the antibiotics.
If a cat is carrying Bartonella henselae, then it may not exhibit any symptoms. Cats may be bacteremic for weeks to years, but infection is more common in young cats. Transmission to humans is thought to occur via flea feces inoculated into a cat scratch or bite, and transmission between cats occurs only in the presence of fleas. Therefore, elimination and control of fleas in the cat's environment are key to prevention of infection in both cats and humans.
History
The condition that later became known as bacillary angiomatosis was first described by Stoler and associates in 1983.[4] Being unaware of its infectious origin, it was originally called epithelioid angiomatosis.[5] Following documentation of bacilli in Warthin-Starry stains and by electron microscopy in a series of cases by LeBoit and colleagues, the term bacillary angiomatosis was widely adopted.[6]
See also
References
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- ↑ Stoler MH, Bonfiglio TA, Steigbigel RT, Pereira M. An atypical subcutaneous infection associated with acquired immune deficiency syndrome. Am J Clin Pathol. 1983 Nov;80(5):714-8
- ↑ Cockerell CJ, Whitlow MA, Webster GF, Friedman-Kien AE. Epithelioid angiomatosis: a distinct vascular disorder in patients with the acquired immunodeficiency syndrome or AIDS-related complex. Lancet. 1987 Sep 19;2(8560):654-6
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
