Bartonella

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This article is about the bacteria. For the disease, see Bartonellosis.
Bartonella
Bartonella.jpg
Scientific classification
Kingdom:
Bacteria
Phylum:
Proteobacteria
Class:
Alphaproteobacteria
Order:
Rhizobiales
Family:
Bartonellaceae

Gieszczykiewicz 1939
Genus:
Bartonella

Strong et al. 1915
Species[1]
Synonyms[1]
  • Bartonia Strong et al. 1913
  • Grahamella (ex Brumpt 1911) Ristic and Kreier 1984
  • Rochalimaea (Macchiavello 1947) Krieg 1961

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Bartonella is a genus of Gram-negative bacteria. It is the only genus in the family Bartonellaceae.[2][3] Facultative intracellular parasites, Bartonella species can infect healthy people, but are considered especially important as opportunistic pathogens.[4] Bartonella species are transmitted by vectors such as ticks, fleas, sand flies, and mosquitoes. At least eight Bartonella species or subspecies are known to infect humans.[5]

Bartonella henselae is the organism responsible for cat scratch disease, a self-limited disease except in immunocompromised hosts.

History

Bartonella species have been infecting humans for thousands of years, as demonstrated by Bartonella quintana DNA in a 4000-year-old tooth.[6] The genus is named for Alberto Leonardo Barton Thompson (1871–October 26, 1950), a Peruvian scientist born in Argentina.

Infection cycle

The currently accepted model explaining the infection cycle holds that the transmitting vectors are blood-sucking arthropods and the reservoir hosts are mammals. Immediately after infection, the bacteria colonize a primary niche, the endothelial cells. Every five days, some of the Bartonella bacteria in the endothelial cells are released into the blood stream, where they infect erythrocytes. The bacteria then invade a phagosomal membrane inside the erythrocytes, where they multiply until they reach a critical population density. At this point, they simply wait until they are taken up with the erythrocytes by a blood-sucking arthropod.

Though some studies have found "no definitive evidence of transmission by a tick to a vertebrate host," [7][8] Bartonella species are well-known to be transmissible to both animals and humans through various other vectors, such as fleas, lice, and sand flies.[9] Recent studies have shown a strong correlation between tick exposure and bartonellosis,[9][10] including human bartonellosis. Bartonella bacteria are associated with cat-scratch disease, but a study in 2010 concluded, "Clinicians should be aware that . . . a history of an animal scratch or bite is not necessary for disease transmission." [11] All current Bartonella species identified in canines are human pathogens.[12]

Pathophysiology

Bartonella infections are remarkable in the wide range of symptoms they can produce. The course of the diseases (acute or chronic) and the underlying pathologies are highly variable.[13]

Bartonella pathophysiology in humans
Species Human reservoir or
incidental host?		 Animal
reservoir		 Pathophysiology Distribution
B. bacilliformis Reservoir Causes Carrion's disease (Oroya fever, Verruga peruana) Peru, Ecuador, and Colombia
B. quintana Reservoir Causes trench fever, bacillary angiomatosis, and endocarditis Worldwide
B. clarridgeiae Incidental Domestic cat Cat scratch disease
B. elizabethae Incidental Rat Endocarditis
B. grahamii Incidental Mouse Endocarditis and neuroretinitis
B. henselae Incidental Domestic cat Cat scratch disease, bacillary angiomatosis, peliosis hepatis, endocarditis, bacteremia with fever, and neuroretinitis Worldwide
B. koehlerae Incidental Domestic cat
B. naantaliensis Reservoir Myotis daubentonii
B. vinsonii Incidental Mouse, dog, domestic cat
B. washoensis Incidental Squirrel Myocarditis
B. rochalimae Incidental Unknown Carrion's disease-like symptoms
References:[14][15][16][17]

Treatment

Treatment is dependent on which species or strain of Bartonella is found in a given patient. While Bartonella species are susceptible to a number of standard antibiotics in vitro — macrolides and tetracycline, for example — the efficacy of antibiotic treatment in immunocompetent individuals is uncertain.[13] Immunocompromised patients should be treated with antibiotics because they are particularly susceptible to systemic disease and bacteremia. Drugs of particular effectiveness include trimethoprim-sulfamethoxazole, gentamicin, ciprofloxacin, and rifampin; B. henselae is generally resistant to penicillin, amoxicillin, and nafcillin.[13]

Epidemiology

Homeless intravenous drug users are at high risk for Bartonella infections, particularly B. elizabethae. B. elizabethae seropositivity rates in this population range from 12.5% in Los Angeles,[18] to 33% in Baltimore, Maryland,[19] 46% in New York City,[20] and 39% in Sweden.[21]

References

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  20. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  21. ↑ Lua error in package.lua at line 80: module 'strict' not found.

External links

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