Bentazepam

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Bentazepam
Bentazepam.svg
Systematic (IUPAC) name
5-phenyl-3,4,6,7,8,9-hexahydro-[1]benzothiolo[2,3-e][1,4]diazepin-2-one
Clinical data
Trade names Tiadipona (ES)
AHFS/Drugs.com International Drug Names
Legal status
Routes of
administration
Oral (tablets)
Pharmacokinetic data
Metabolism Hepatic
Biological half-life 2–4 hours
Excretion Renal
Identifiers
CAS Number 29462-18-8 YesY
PubChem CID: 34592
ChemSpider 11248641 YesY
UNII 66JKK43S1Z YesY
KEGG D03083 YesY
ChEMBL CHEMBL1521495 N
Chemical data
Formula C17H16N2OS
Molecular mass 296.387 g/mol
  • O=C1CN=C(C2=CC=CC=C2)C3=C(N1)SC4=C3CCCC4
  • InChI=1S/C17H16N2OS/c20-14-10-18-16(11-6-2-1-3-7-11)15-12-8-4-5-9-13(12)21-17(15)19-14/h1-3,6-7H,4-5,8-10H2,(H,19,20) YesY
  • Key:AIZFEOPQVZBNGH-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Bentazepam[1] (also known as Thiadipone, Tiadipona) is a thienodiazepine which is a benzodiazepine analog.[2] It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Peak plasma rates are achieved in around 2,5 hours after oral administration.[3] The elimination half-life is between approximately 2–4 hours.[2][4] Bentazepam is effective as an anxiolytic. A severe benzodiazepine overdose with bentazepam may result in coma and respiratory failure.[5] Adverse effects include dry mouth, somnolence, asthenia, dyspepsia, constipation, nausea[6] and drug-induced lymphocytic colitis has been associated with bentazepam.[7][8] Severe liver damage and hepatitis has also been associated with bentazepam.[9][10][11] Whilst liver failure from bentazepam is considered to be rare, liver function monitoring has been recommended for all patients taking bentazepam.[12]

See also

References

  1. DE Patent 2005276
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