Brain-specific angiogenesis inhibitor 3
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.[1][2]
BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[2]
The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.[3] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.
References
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- ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Marc F. Bolliger, David C. Martinelli, and Thomas C. Südhof. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. PNAS 2011 ; published ahead of print January 24, 2011, doi:10.1073/pnas.1019577108
Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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