Butaclamol

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Butaclamol
Butaclamol.svg
Systematic (IUPAC) name
(3S,4aS,13bS)-3-(2-Methyl-2-propanyl)-2,3,4,4a,8,9,13b,14-octahydro-1H-benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-3-ol
Identifiers
CAS Number 36504-93-5
ATC code none
PubChem CID: 37459
IUPHAR/BPS 62
ChemSpider 34364
UNII A7A2802VNL YesY
ChEBI CHEBI:73298 YesY
ChEMBL CHEMBL479587 YesY
Chemical data
Formula C25H31NO
Molecular mass 361.52 g/mol
  • CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O

Butaclamol (AY-23,028) is an antipsychotic which was never marketed.[1] Sold as the hydrochloride salt for use in research, the compound acts as a dopamine receptor antagonist.[2]

Chemistry

pKa = 7.15 (uncorrected for ionic strength)[3]

See also

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5=SEARCH_CONCAT_PNO%7CBRAND_KEY&N4=D033%7CSIGMA&N25=0&QS=ON&F=SPEC
  3. ↑ F. A. Chrzanowski, B. A. McGrogan, B. E. Maryanoff (1985). "The pKa of butaclamol and the mode of butaclamol binding to central dopamine receptors." J. Med. Chem. 28 399-400.

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