CCL3

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Chemokine (C-C motif) ligand 3
Protein CCL3 PDB 1b50.png
PDB rendering based on 1b50.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CCL3 ; G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
External IDs OMIM182283 HomoloGene88430 GeneCards: CCL3 Gene
RNA expression pattern
PBB GE CCL3 205114 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6348 20302
Ensembl ENSG00000274221 ENSMUSG00000000982
UniProt P10147 P10855
RefSeq (mRNA) NM_002983 NM_011337
RefSeq (protein) NP_002974 NP_035467
Location (UCSC) Chr 17:
36.09 – 36.09 Mb
Chr 11:
83.65 – 83.65 Mb
PubMed search [1] [2]

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.[1]

Function

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes[2] through binding to the receptors CCR1, CCR4 and CCR5.[1]

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).[3][1]

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.[4]

Interactions

CCL3 has been shown to interact with CCL4.[5] Attracts macrophages, monocytes and neutrophils.

See also

References

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Further reading

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