CCL4

For carbon tetrachloride, with formula CCl4, see Carbon tetrachloride.

Chemokine (C-C motif) ligand 4
PDB rendering based on 1hum.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1HUM, 1HUN, 1JE4, 2FFK, 2FIN, 2X6L, 3TN2, 4RAL
Identifiers
Symbols	CCL4 ; ACT2; AT744.1; G-26; HC21; LAG-1; LAG1; MIP-1-beta; MIP1B; MIP1B1; SCYA2; SCYA4
External IDs	OMIM: 182284 MGI: 98261 HomoloGene: 48153 GeneCards: CCL4 Gene
Gene ontology Molecular function • cytokine activity • protein binding • chemokine activity • CCR1 chemokine receptor binding • CCR5 chemokine receptor binding • identical protein binding Cellular component • extracellular region • extracellular space Biological process • monocyte chemotaxis • movement of cell or subcellular component • inflammatory response • immune response • cell adhesion • establishment or maintenance of cell polarity • signal transduction • G-protein coupled receptor signaling pathway • cell-cell signaling • response to virus • response to toxic substance • neutrophil chemotaxis • positive regulation of GTPase activity • negative regulation by host of viral transcription • eosinophil chemotaxis • positive regulation of inflammatory response • positive regulation of calcium-mediated signaling • positive regulation of calcium ion transport • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • positive regulation of natural killer cell chemotaxis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6351	20303
Ensembl	ENSG00000275302	ENSMUSG00000018930
UniProt	P13236	P14097
RefSeq (mRNA)	NM_002984	NM_013652
RefSeq (protein)	NP_002975	NP_038680
Location (UCSC)	Chr 17: 36.1 – 36.11 Mb	Chr 11: 83.66 – 83.66 Mb
PubMed search	[1]	[2]

Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene.

Function

CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells.

CCL4 is a major HIV-suppressive factor produced by CD8+ T cells.

Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.

Interactions

CCL4 has been shown to interact with CCL3.

See also

• Macrophage inflammatory protein