CCL8

Chemokine (C-C motif) ligand 8
250px Crystallographic structure of human C-C motif chemokine 8.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ESR
Identifiers
Symbols	CCL8 ; HC14; MCP-2; MCP2; SCYA10; SCYA8
External IDs	OMIM: 602283 HomoloGene: 48362 GeneCards: CCL8 Gene
Gene ontology Molecular function • protein kinase activity • chemokine activity • heparin binding • phospholipase activator activity • CCR chemokine receptor binding Cellular component • extracellular space • cell Biological process • monocyte chemotaxis • positive regulation of leukocyte migration • protein phosphorylation • calcium ion transport • cellular calcium ion homeostasis • exocytosis • chemotaxis • inflammatory response • signal transduction • G-protein coupled receptor signaling pathway • cell-cell signaling • response to virus • neutrophil chemotaxis • positive regulation of GTPase activity • eosinophil chemotaxis • lymphocyte chemotaxis • chemokine-mediated signaling pathway • positive regulation of ERK1 and ERK2 cascade • negative regulation of leukocyte proliferation • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6355	n/a
Ensembl	ENSG00000108700	n/a
UniProt	P80075	n/a
RefSeq (mRNA)	NM_005623	n/a
RefSeq (protein)	NP_005614	n/a
Location (UCSC)	Chr 17: 34.32 – 34.32 Mb	n/a
PubMed search	[1]	n/a

Chemokine (C-C motif) ligand 8, also known as monocyte chemoattractant protein 2 (MCP-2), is a protein that in humans is encoded by the CCL8 gene.

CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates a many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5.

Monocyte chemotactic protein 2 (MCP-2) is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. MCP-2 is a potent inhibitor of HIV-1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV-1.