CGK733 fraud
CGK733 was a synthetic chemical substance which was reported in 2006 to have remarkable properties in reversing cell senescence (aging).[1] However, the entire work behind the discovery of this compound has since been found to be falsified and the authors of the original reports have retracted all their claims.[2][3]
CGK733 was claimed to be an inhibitor of ATM/ATR kinases,[4][5] which are involved in DNA damage repair. CGK was claimed to extend the lifetime of cultured cells by approximately 20 divisions, or roughly 25%, specifically in mammalian cells.
The original report garnered scientific attention,[6] but was retracted in 2008.[7] The retraction states that the screen to identify CGK733 as an anti-senescence agent was not carried out; experiments exploring the cellular effects of CGK733 were misrepresented; the identification of ATM as the target of CGK733 was fabricated; a compound which was essential for ATM target validation had not been synthesized; and the chemical structure of CGK733 was misrepresented.[7]
The principal investigator, Tae Kook Kim, and several associates were consequently suspended from their positions at the Korea Advanced Institute of Science & Technology.[2]
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found. (Retracted, see PMID 18560433)
- ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ 7.0 7.1 Lua error in package.lua at line 80: module 'strict' not found.
