CXCL11

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Chemokine (C-X-C motif) ligand 11
250px
PDB rendering based on 1rjt.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CXCL11 ; H174; I-TAC; IP-9; IP9; SCYB11; SCYB9B; b-R1
External IDs OMIM604852 MGI1860203 HomoloGene3944 GeneCards: CXCL11 Gene
RNA expression pattern
File:PBB GE CXCL11 210163 at tn.png
File:PBB GE CXCL11 211122 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6373 56066
Ensembl ENSG00000169248 n/a
UniProt O14625 Q9JHH5
RefSeq (mRNA) NM_001302123 NM_019494.1
RefSeq (protein) NP_001289052 NP_062367.1
Location (UCSC) Chr 4:
76.03 – 76.04 Mb
n/a
PubMed search [1] [2]

C-X-C motif chemokine 11 is a protein that in humans is encoded by the CXCL11 gene. [1]

C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.[2]

Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α.[3] This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10.[2][4] CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.[5][6]

References

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Further reading

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