Carbinoxamine

Carbinoxamine

File:Carbinoxamine.svg
Systematic (IUPAC) name
2-[(4-Chlorophenyl)-pyridin-2-yl-methoxy]-N,N- dimethyl-ethanamine
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a606008
Pregnancy category	C
Legal status	4 mg is FDA approved
Routes of administration	Oral: 4 mg tablet or 4 mg/5 mL liquid
Pharmacokinetic data
Biological half-life	10 to 20 hours
Identifiers
CAS Number	486-16-8 Y
ATC code	R06AA08 (WHO)
PubChem	CID: 2564
IUPHAR/BPS	7139
DrugBank	DB00748 Y
ChemSpider	2466 Y
UNII	VED9E376NC Y
KEGG	D07617 Y
ChEBI	CHEBI:3398 Y
ChEMBL	CHEMBL864 Y
Chemical data
Formula	C16H19ClN2O
Molecular mass	290.788 g/mol
SMILES Clc1ccc(cc1)C(OCCN(C)C)c2ncccc2
InChI InChI=1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3 Y Key:OJFSXZCBGQGRNV-UHFFFAOYSA-N Y
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Carbinoxamine (Clistin, Palgic, Rondec, Rhinopront) is a antihistamine and anticholinergic agent. It was first launched in the United States by the McNeil Corporation under the brand name Clistin. It is now available under the brand name Palgic as 4 mg tablets or 4 mg/5 mL liquid. It is approved by the U.S. Food and Drug Administration (FDA) (specifically at the 4 mg dose/strength) for hay fever (a.k.a. allergic rhinitis, SAR and PAR); vasomotor rhinitis; mild urticaria; angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist. The maleic acid acid salt of the levorotatory isomer is sold as the prescription drug rotoxamine.

Carbinoxamine is available in various countries around the world by itself, combined with decongestants such as pseudoephedrine, and also with other ingredients including paracetamol, aspirin, and codeine.

In June 2006 the FDA announced that more than 120 branded pharmacy products containing carbinoxamine were being illegally marketed and demanded they be removed from the marketplace. This action was precipitated by twenty-one reported deaths in children under the age of two who had been administered carbinoxamine-containing products. Despite the fact that the drug had not been studied in this age group, a multitude of OTC preparations containing carbinoxamine were being marketed for infants and toddlers. At present, all carbinoxamine-containing formulations are approved only for adults or children ages 3 or older.

Carbinoxamine is used in the treatment of severe itching in patients with CD5.

See also

• Carbinoxamine/pseudoephedrine
• Tofenacin
• Clemastine
• Captodiamine