Carisbamate

Carisbamate

Systematic (IUPAC) name
(S)-2-O-carbamoyl-1-o-chlorophenyl-ethanol
Identifiers
CAS Number	194085-75-1 Y
ATC code	N03AX19 (WHO)
PubChem	CID: 9942577
ChemSpider	8118189 Y
UNII	P7725I9V3Z Y
ChEMBL	CHEMBL2087003 N
Chemical data
Formula	C9H10ClNO3
Molecular mass	215.633 g/mol
SMILES Clc1ccccc1[C@@H](O)COC(=O)N
InChI InChI=1S/C9H10ClNO3/c10-7-4-2-1-3-6(7)8(12)5-14-9(11)13/h1-4,8,12H,5H2,(H2,11,13)/t8-/m0/s1 Y Key:OLBWFRRUHYQABZ-QMMMGPOBSA-N Y
NY (what is this?)  (verify)

Carisbamate (YKP 509, proposed trade name Comfyde) is an experimental anticonvulsant drug under development by Johnson & Johnson Pharmaceutical Research and Development. In 1998, the compound was in-licensed from SK Corp. (currently Life Science Business Division of SK Holdings), a South Korean company. A phase II clinical trial in the treatment of partial seizures demonstrated that the compound has efficacy in the treatment of partial seizures and a good safety profile. Since late 2006, the compound has been undergoing a large multicenter phase III clinical trial for the treatment of partial seizures. Its mechanism of action is unknown.

On October 24, 2008, Johnson & Johnson announced that it had submitted a New Drug Application to the U.S. Food and Drug Administration (FDA) for carisbamate. Carisbamate has received provisional approval by the FDA to be marketed under the brand name of Comfyde. However, on August 21, 2009, Johnson & Johnson reported that the FDA had failed to give marketing approval.

A double-blind, placebo-controlled trial cf carisbamate in 323 patients with migraine failed to demonstrate that the active drug was more effective than placebo. However, carisbamate was well tolerated at doses up to 600 mg/day.