Celiprolol

Celiprolol

Systematic (IUPAC) name
(RS)-N'-{3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-N,N-diethylurea
Clinical data
AHFS/Drugs.com	International Drug Names
Pharmacokinetic data
Bioavailability	30-70%
Biological half-life	5 hours
Identifiers
CAS Number	56980-93-9
ATC code	C07AB08 (WHO)
PubChem	CID: 2663
DrugBank	DB04846 Y
ChemSpider	2563
UNII	DRB57K47QC Y
KEGG	D07660
ChEMBL	CHEMBL27810
Chemical data
Formula	C20H33N3O4
Molecular mass	379.49 g/mol
SMILES O=C(N(CC)CC)Nc1ccc(OCC(O)CNC(C)(C)C)c(c1)C(=O)C

Celiprolol (brand names Cardem, Selectol, Celipres, Celipro, Celol, Cordiax, Dilanorm) is a medication in the class of beta blockers, used in the treatment of high blood pressure. It has a unique pharmacology: it is a selective β1 receptor antagonist, but a β2 receptor partial agonist. It is also a weak α2 receptor antagonist.

In 2010 a clinical trial has suggested a use for this medication in the prevention of vascular complications of a rare inherited disease called vascular Ehlers–Danlos syndrome. This study demonstrated decreased incidence of arterial rupture or dissection (a specific type of arterial rupture in which the layers of the vessel separate prior to complete failure of the artery wall).

External links

• Selectol Summary of Product Characteristics (from the IPHA Medicines Compendium)
• Celiprolol data sheet for New Zealand