Chemoproteomics
Chemoproteomics is an approach to discovering mechanisms for regulating biological pathways for the purpose of designing new pharmaceutical therapies. It is a chemical proteomic method for pharmacological discovery research.
Contents
Introduction
Chemoproteomics can enable drug discovery.[1] It is a method for identifying protein targets and potential off-target activity.[2]
The science can be categorized into three categories: affinity pull-down, Capture Compound Mass Spectrometry and activity-based protein profiling.[3]
Method
A linker molecule connects a small molecule chemical probe (or library of chemical probes) with an analytically detectable bead or other agent for detection or separation.[4]
See also
References
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