Chlorphentermine

Chlorphentermine

Systematic (IUPAC) name
1-(4-chlorophenyl)-2-methylpropan-2-amine
Clinical data
Legal status	Schedule III (US)
Routes of administration	Oral, Insufflated, Rectal
Pharmacokinetic data
Biological half-life	40 hours
Excretion	Renal
Identifiers
CAS Number	461-78-9 N Template:CAS
ATC code	A08AA (WHO)
PubChem	CID: 10007
DrugBank	DB01556 Y
ChemSpider	9613 Y
UNII	NHW07912O7 Y
KEGG	C07559 Y
ChEMBL	CHEMBL1201269 N
Synonyms	p-Chloro-α,α-dimethylphenethylamine
Chemical data
Formula	C10H14ClN
Molecular mass	183.68 g/mol
SMILES Clc1ccc(cc1)CC(N)(C)C
InChI InChI=1S/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3 Y Key:ZCKAMNXUHHNZLN-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Chlorphentermine (trade names Apsedon, Desopimon, Lucofen) is an appetite suppressant of the phenethylamine class. Developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine, which is still in current use.

Chlorphentermine itself is a relatively weak stimulant with little abuse potential, but is classed as a Schedule III drug in the USA due mainly to its similarity to other appetite suppressants such as diethylpropion which have been more widely abused. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.

See also

• Phentermine
• Clortermine
• Methylenedioxyphentermine
• Fenfluramine
• Aminorex
• Etolorex
• Cloforex